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Nathan Goodyear

Tryptophan availability and the susceptibility to stress in multiple sclerosis: a hypot... - 0 views

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    low serum and CSF tryptophan found in patients with chronic MS.  This points to disordered tryptophan metabolism
Nathan Goodyear

Mechanisms dependent on tryptophan catabolism regulate immune responses in pr... - 0 views

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    Disordered Tryptophan metabolism is a useful biomarker for those with Sjogren's syndrome.  This study found an increased degradation of Tryptophan and increased IDO activity that correlated with increased severity of Sjogren's syndrome.
Nathan Goodyear

Tryptophan-Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impa... - 0 views

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    Disordered tryptophan metabolism in depression
Nathan Goodyear

Serum Tryptophan, Kynurenine, and Neopterin in Patients with Guillain-Barre-Syndrome (G... - 0 views

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    disordered tryptophan metabolism in GB and MS.
Nathan Goodyear

Interferon-alpha-induced changes in tryptoph... [Biol Psychiatry. 2003] - PubMed - NCBI - 0 views

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    paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels.  Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation
Nathan Goodyear

Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression - 0 views

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    disordered tryptophan metabolism and MS
Nathan Goodyear

Kynurenine Metabolites and Migraine: Experimental Studies and Therapeutic Perspectives - 0 views

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    Disordered tryptophan metabolism and migraine headaches.
Nathan Goodyear

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States - 0 views

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    review of studies looking at kyneurenine pathway and it's contribution to neurodegenerative disorders and mood disorders
Nathan Goodyear

Targeting the IDO1 pathway in cancer: from bench to bedside | Journal of Hematology & O... - 0 views

  • Kyn is generated via two major routes: in peripheral tissues, controlled by the rate-limiting enzymes indoleamine 2, 3-dioxygenase 1 (IDO1) and indoleamine 2, 3-dioxygenase 2 (IDO2), and the hepatic route, in which tryptophan 2, 3-dioxygenase (TDO) is the rate-limiting enzyme
Nathan Goodyear

Characterization of the Kynurenine Pathway in Human Neurons - 0 views

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    review of the kynurenine pathway 
Nathan Goodyear

Untitled Page - 0 views

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    review of inflammation, glutamic acid, glial activation and depression
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